Pancreatic Cancer Aggressiveness Potentially Linked to Microenvironment Protein Marker

2017/1/9 13:04:06

"Taken together, our results revealed that cellular crosstalk and [a] hostile environment lead to profound modifications of [cancer-associated fibroblast] activity and consequently impact on tumor cell abilities, tumor evolution, and patients' fate," senior author Richard Tomasini, a cancer researcher at the French National Institute of Health and Medical Research (INSERM), and his co-authors wrote.

 


NEW YORK (GenomeWeb) – A team from France and Belgium has identified a potential protein biomarker in tissue surrounding pancreatic cancer tumors that appears to correspond to more aggressive forms of the disease.

 

As they reported in the Journal of Clinical Investigation, the researchers used mass spectrometry to assess stroma and tumor samples from four individuals with pancreatic ductal adenocarcinoma, identifying apparent ties between the annexin A6 (ANXA6) protein in cancer-associated fibroblast cells and aggressiveness of the neighboring tumor.

 

In particular, their results hint that interactions between pancreatic ductal carcinoma tumors and cancer-associated fibroblast cells surrounding them are bolstered by extracellular vesicles in the tumor microenvironment that contain the ANXA6 protein.

 

"Taken together, our results revealed that cellular crosstalk and [a] hostile environment lead to profound modifications of [cancer-associated fibroblast] activity and consequently impact on tumor cell abilities, tumor evolution, and patients' fate," senior author Richard Tomasini, a cancer researcher at the French National Institute of Health and Medical Research (INSERM), and his co-authors wrote.

 

[…]

https://www.genomeweb.com/proteomics-p ... y-linked-microenvironment

 

 

 

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